1. DSpaceCRIS@UNITEN
  2. UNITEN Publication
  3. UNITEN Scholarly Publication
Please use this identifier to cite or link to this item: http://dspace.uniten.edu.my/jspui/handle/123456789/13314
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dc.contributor.authorFadaeinasab, M.en_US
dc.contributor.authorKarimian, H.en_US
dc.contributor.authorOmar, H.en_US
dc.contributor.authorTaha, H.en_US
dc.contributor.authorkhorasani, A.en_US
dc.contributor.authorBanisalam, B.en_US
dc.contributor.authorAziz Ketuly, K.en_US
dc.contributor.authorAbdullah, Z.en_US
dc.date.accessioned2020-02-03T03:31:46Z-
dc.date.available2020-02-03T03:31:46Z-
dc.date.issued2019-
dc.description.abstractOne new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC 50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
dc.language.isoenen_US
dc.titleReflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cellsen_US
dc.typeArticleen_US
dc.identifier.doi10.1080/10286020.2019.1588888-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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