Please use this identifier to cite or link to this item:
http://dspace.uniten.edu.my/jspui/handle/123456789/13314
Title: | Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells | Authors: | Fadaeinasab, M. Karimian, H. Omar, H. Taha, H. khorasani, A. Banisalam, B. Aziz Ketuly, K. Abdullah, Z. |
Issue Date: | 2019 | Abstract: | One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC 50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. | DOI: | 10.1080/10286020.2019.1588888 |
Appears in Collections: | UNITEN Scholarly Publication |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.