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Title: Anti-inflammatory trends of new benzimidazole derivatives
Authors: Bukhari, S.N.A. 
Lauro, G. 
Jantan, I. 
Chee, C.F. 
Amjad, M.W. 
Bifulco, G. 
Sher, H. 
Abdullah, I. 
Rahman, N.A. 
Issue Date: 2016
Journal: Future Medicinal Chemistry Volume 8, Issue 16, October 2016, Pages 1953-1967 
Abstract: Aim: In present study, the anti-inflammatory activities of a new series of benzimidazole derivatives were studied, investigating their inhibition of secretory phospholipase A2, lipoxygenase, COXs and lipopolysaccharide-induced secretion of TNF-α and IL-6 in mouse RAW264.7 macrophages. Results: Synthesized compounds effectively inhibited proinflammatory enzymes and cytokines. Conclusion: A strong inhibition of secretory phospholipases A2 was exhibited by benzimidazole derivatives with trifluoromethyl and methoxy substitutions at position 4 of attached phenyl, whereas compound 8 containing pyridine ring substituted with amino group showed very potent 5-lipoxygenase inhibition. Molecular docking experiments were carried out to elucidate the molecular basis of the observed inhibitory activities. © 2016 Future Science Ltd.
DOI: 10.4155/fmc-2016-0062
Appears in Collections:COE Scholarly Publication

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