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|Title:||Anti-inflammatory trends of new benzimidazole derivatives||Authors:||Bukhari, S.N.A.
|Issue Date:||2016||Journal:||Future Medicinal Chemistry Volume 8, Issue 16, October 2016, Pages 1953-1967||Abstract:||Aim: In present study, the anti-inflammatory activities of a new series of benzimidazole derivatives were studied, investigating their inhibition of secretory phospholipase A2, lipoxygenase, COXs and lipopolysaccharide-induced secretion of TNF-α and IL-6 in mouse RAW264.7 macrophages. Results: Synthesized compounds effectively inhibited proinflammatory enzymes and cytokines. Conclusion: A strong inhibition of secretory phospholipases A2 was exhibited by benzimidazole derivatives with trifluoromethyl and methoxy substitutions at position 4 of attached phenyl, whereas compound 8 containing pyridine ring substituted with amino group showed very potent 5-lipoxygenase inhibition. Molecular docking experiments were carried out to elucidate the molecular basis of the observed inhibitory activities. © 2016 Future Science Ltd.||DOI:||10.4155/fmc-2016-0062|
|Appears in Collections:||COE Scholarly Publication|
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