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Title: An efficient one-pot synthesis of flavones
Authors: Chee, C.F. 
Buckle, M.J.C. 
Rahman, N.A. 
Issue Date: 2011
Abstract: Flavones were prepared using a one-pot procedure starting from the corresponding 2′-hydroxyacetophenones. The latter were treated with 3 equiv of aroyl chloride in wet K2CO3/acetone (1% w/w water) to afford a good yield of flavone and a smaller amount of 3-aroylflavone. Evidence was obtained that the reaction proceeds via a triketone intermediate. When the reactants were heated in 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and pyridine, the 3-aroylflavone was obtained exclusively. Use of a stoichiometric amount of aroyl chloride afforded only the corresponding flavone. © 2011 Elsevier Ltd. All rights reserved.
Appears in Collections:COE Scholarly Publication

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