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Title: | All serotypes of dengue virus induce HLA-A2 major histocompatibility complex class I promoter activity in human liver cells | Authors: | Othman, S. Rahman, N.A. Yusof, R. |
Issue Date: | 2010 | Abstract: | In contrast to many viruses that escape the host's immune responses by suppressing the major histocompatibility complex (MHC) class I pathway, flaviviruses have been shown to up-regulate the cell surface expression of MHC class I complex. The mechanism by which dengue virus (DV) achieves this up-regulation remains unclear. Our investigation on the HLA-A2 gene in human liver cells demonstrated that all four serotypes of dengue virus, DV1 to DV4, resulted in variable degrees of promoter induction. This illustrates the importance of MHC class I transcription regulation in primary infections by different DV serotypes that may have even greater impact in secondary infections, associated with increased disease severity. © 2010 Royal Society of Tropical Medicine and Hygiene. | URI: | http://dspace.uniten.edu.my/jspui/handle/123456789/9797 |
Appears in Collections: | COE Scholarly Publication |
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